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Onfianti-seizure drug associated with rare skin condition


Onfi (clobazam) is an anti-seizure drug in the category of drugs called benzodiazepines. Onfi is often prescribed in combination with other medications in an attempt to prevent seizures associated with a severe form of epilepsy called Lennox-Gaustaut syndrome.

Manufactured by the Danish pharmaceutical company, Lundbeck, Onfi was approved by the FDA in October of 2011. By September of 2013 over 30,000 Americans had been prescribed Onfi.


FDA Safety Warning for Onfi Skin Reactions

On December 3, 2013, the FDA warned that the anti-seizure drug Onfi can cause rare but serious skin reactions that can result in permanent harm and death.

The Drug Safety Communication came after a review of adverse events linked to Onfi to 20 skin reactions involving Stevens-Johnsons Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). The FDA is advising clinicians to closely monitor patients taking Onfi for SJS and TEN, especially at the start of therapy or when the drug is reintroduced.


Steven-Johnsons Syndrome and Toxic Epidermal Necrolysis

Stevens-Johnsons Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but severe, life-threatening skin reactions that cause the top layer of skin to detach and fall off in a large sheet. Sloughing skin may appear burned, while blisters may also develop on mucous membranes located at the eyes, mouth, and genitals and ultimately spread from all over the body to inside the intestines, lungs, and stomach.

Onfi skin reactions are extremely dangerous, painful, and disfiguring and can lead not only to life-threatening infections, but also organ damage, blindness, and death.

Common Symptoms include, but are not limited to:

  • Pain of the Skin
  • Red or Purple Rashes that Spread from the Face
  • Swelling of the Face or Tongue
  • Hives
  • Skins Detaching or Sloughing Off in Sheets
  • Blisters on the Mouth, Nose, or Eyes
  • Hives
  • Tiredness
  • Fever, Chills, Headaches, Muscle Aches, Joint Pains
  • Sore Throat

If you feel that you developed Stevens Johnsons Syndrome or Toxic Epidermal Necrolysis as a result of your Onfi usage, you should consider contacting an Onfi attorney. Contact an Onfi attorney like TorHoerman Law to make sure your legal rights are considered. We are offering a no charge, no obligation review of your medical history in order to explore your legal rights.

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