Onglyza and Kombiglyze XRHeart Failure and Pancreatic Cancer Risks

Onglyza and Kombiglyze XR

CASE UPDATE: Onglyza Heart Failure Lawsuits Consolidated

February 2018: 80 Onglyza heart failure lawsuits were consolidated before the U.S. District Court, Eastern District of Kentucky.

Read More Updates

If you or a loved one has taken Onglyza or Kombiglyze XR and subsequently experienced serious injuries such as heart failure, pancreatitis, or pancreatic cancer, you may be entitled to compensation for your injuries through an Onglyza lawsuit. Contact TorHoerman Law to speak with an Onglyza injury lawyer today for a free, no-obligation case consultation. Learn about your legal options with the help of a professional bad drug lawyer from TorHoerman Law and begin the process of recovery through an Onglyza heart failure lawsuit or Onglyza pancreatic cancer lawsuit.

You can also use our chatbot below to get an instant online case evaluation to see if you qualify for compensation!

You are not alone on the road to recovery. Contact TorHoerman Law and learn more about how our firm can serve you.



Onglyza and Kombiglyze XR

Onglyza (saxagliptin) and Kombiglyze XR (saxagliptin and metformin HCl extended-release) are part of a class of medications known as Incretin Mimetics, which is further divided into a category called dipeptidyl peptidase-4 (DPP-4) inhibitors. Used for individuals suffering from Type 2 diabetes who do not suffer from diabetic ketoacidosis, the intended purpose of these Type 2 diabetes drugs is to stimulate insulin production in the pancreas after meals to control blood sugar.

Kombiglyze XR is a longer-acting version, which combines Onglyza with metformin, an older Type 2 diabetes drug.

Onglyza and Kombiglyze XR are both manufactured by AstraZeneca and Bristol Myers Squibb. They can potentially increase the risk of severe, potentially life-threatening side effects, and in an Onglyza heart failure lawsuit and Onglyza pancreatic cancer lawsuit that has been filed, plaintiffs allege the drugs increased the risk of both heart failure and pancreatic cancer.



Onglyza Injuries & Risks

Onglyza and Kombiglyze XR have been linked to a number of serious and even life-threatening injuries, including:

  • pancreatitis
  • pancreatic cancer
  • heart failure
  • congestive heart failure
  • death.

If you or a loved one suffered any of these injuries after taking Onglyza or Kombiglyze XR, you may qualify for an Onglyza heart failure lawsuit or an Onglyza pancreatic cancer lawsuit. Contact an Onglyza heart failure lawyer to discuss your legal options today.


Onglyza Linked to Heart Failure

Cardiovascular disease is the most common cause of death of both men and women in the United States. According to the CDC, “about 610,000 people die of heart disease in the United States every year – that’s 1 in every 4 deaths.”

Heart failure, a type of cardiovascular disease, can occur when the heart isn’t pumping as much blood as it should be. This prevents the body from obtaining the required amount of blood and oxygen needed to function. If left untreated, heart failure can get worse, inevitably causing potentially deadly health consequences.

For Type 2 diabetes patients taking Onglyza, the connection between the drug and cardiovascular risks are alarming. Due to a growing concern, the U.S. Food & Drug Administration (FDA) opened up an investigation between the drug and the connection to heart failure in 2015. As a result of that investigation, additional warnings were issued to include the risk of heart failure on both Onglyza and Kombiglyze XR.


Onglyza Linked to Pancreatic Cancer

According to the National Cancer Institute, there were an estimated 68,615 people living with pancreatic cancer in the United States in 2015. It is one of the deadliest cancers because it often goes undetected until its later stages making it difficult to treat.

In 2011, Pancreatitis was added to both Onglyza and Kombiglyze XR’s warning labels. Serious cases can result in pain and suffering, hospitalization, or even death. Pancreatitis can also sometimes be a precursor to pancreatic cancer. In 2013, the FDA launched an investigation into the connection between Onglyza and pancreatic cancer.



Do I Qualify For an Onglyza Lawsuit?

If you are currently taking or were previously taking Onglyza or Kombiglyze XR to treat diabetes and you were subsequently diagnosed with a serious injury, you may qualify for an Onglyza lawsuit. Contact an Onglyza injury lawyer to discuss your injuries and learn whether you qualify for financial compensation for your injuries.

In the unfortunate situation that you are representing a loved one who has passed away due to Onglyza injuries, you can still file a wrongful death lawsuit on their behalf.


Injuries Accepted For an Onglyza Lawsuit

TorHoerman Law is currently accepting cases involving the following injuries:

  • Heart failure
  • Pancreatic cancer
  • Pancreatitis
  • Death

In order to qualify, you or your loved one must have taken Onglyza or Kombiglyze XR prior to being diagnosed with your injuries.



Filing an Onglyza Lawsuit

Before filing an Onglyza lawsuit, you should take the time to familiarize yourself with the civil litigation process so that you know what to expect of your lawsuit.

You should also do everything in your power to mitigate injuries and damages – meaning you should minimize the damages associated with your injuries. This includes seeking proper medical treatment, following your doctor’s orders and, if possible, discontinuing your use of Onglyza or Kombiglyze XR if your doctor allows it.

Your state’s statute of limitations limits the amount of time you have to take legal action after your injury has been diagnosed or occurred, so do not hesitate to take the initial step. First, you should hire a personal injury lawyer to represent you as your Onglyza injury lawyer. Be sure that your attorney has experience in pharmaceutical law and the resources necessary to build your case.

Your Onglyza injury lawyer will gather evidence to prove that liability falls on the manufacturer, AstraZeneca, and Bristol Myers Squibb. They will also use this evidence to assess damages that you incurred as a result of your injuries – this may include both compensatory damages and punitive damages, additional damages that act to punish the manufacturer for their negligent actions.

Your Onglyza injury lawyer will work diligently to gain you a compensated award through a pretrial settlement or a trial verdict.



Hiring an Onglyza Injury Lawyer

Hiring an attorney to act as your Onglyza injury lawyer is a crucial step in the success of any Onglyza heart failure lawsuit or Onglyza pancreatic cancer lawsuit.

You should find a lawyer who is experienced, has the resources necessary to build a strong case for you and is as committed as you are to seeing that your Onlgza lawsuit has a successful outcome.

At TorHoerman Law, we have a team of attorneys who are experienced in product liability and bad drug lawsuits. Our firm works on a contingency fee basis, so our clients do not pay legal fees until they have been awarded compensation for their injuries – no compensation, no fees.

TorHoerman Law is equipped and experienced to handle your Onglyza lawsuit. Contact us today to learn how we can serve you.



Contact TorHoerman Law, Onglyza Injury Law Firm

If you believe you were injured as a result of Onglyza or Kombiglyze XR’s dangerous side effects, please contact our personal injury lawyers today for a free, no-obligation consultation today. Or you can use our chatbot below to get an instant online case evaluation and learn whether you qualify for an Onglyza heart failure lawsuit or Onglyza pancreatic cancer lawsuit right now.



Onglyza Heart Failure Lawsuit | Onglyza Pancreatic Cancer Lawsuit | Onglyza Injury Lawyer
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Litigation Updates

Lawsuit Filed on Behalf of Man who Alleges He Suffered Heart Failure

February 2017 - A diabetes drug lawsuit was filed on behalf of a man who alleges he suffered heart failure, congestive heart failure and acute hypoxic respiratory failure as a result of Onglyza and Kombiglyze XR usage.


Drug Safety Communication Issued to Include Heart Failure Warnings

April 5, 2016 - A drug safety communication was issued to include heart failure warnings for the following drugs: Onglyza and Kombiglyze XR. The label now lists these possible side effects.


Committee Voted to Include Stronger Warnings of Onglyza Heart Risks

April 2015 - The FDA's Endocrinologic and Metabolic Drugs Advisory Committee voted to include stronger warnings of the potential Onglyza heart risks after the results of two studies were published in the New England Journal of Medicine.

Investigation Launched Regarding Onglyza and Potential Risks of Developing Pancreatic Cancer

March 14, 2013 - The FDA launched an investigation into Onglyza and the potential for increased risks of developing pancreatitis and pancreatic cancer.


Safety Review of Onglyza Launched by FDA

February 11, 2014 - The FDA launched a safety review of the alleged increased risk of heart risks associated with Onglyza.


FDA Approved Kombiglyze XR

2010 - Kombiglyze XR is approved for sale by the FDA.


Onglyza Approved by FDA

2009 - The FDA approved Onglyza for sale.

See More


Ault, Alicia. “FDA Panel Backs New Safety Warnings on Two Diabetes Drugs.” Medscape, 14 Apr. 2015,

“Cancer Stat Facts: Pancreatic Cancer.” Surveillance, Epidemiology, and End Results Program, National Cancer Institute,

“FDA Drug Safety Communication: FDA Adds Warnings about Heart Failure Risk to Labels of Type 2 Diabetes Medicines Containing Saxagliptin and Alogliptin.” U.S. Food and Drug Administration Home Page, U.S. Department of Health and Human Services,

“FDA Drug Safety Communication: FDA Investigating Reports of Possible Increased Risk of Pancreatitis and Pre-Cancerous Findings of the Pancreas from Incretin Mimetic Drugs for Type 2 Diabetes.” U.S. Food and Drug Administration, U.S. Department of Health and Human Services,

“FDA Drug Safety Communication: FDA to Review Heart Failure Risk with Diabetes Drug Saxagliptin (Marketed as Onglyza and Kombiglyze XR).” U.S. Food and Drug Administration, U.S. Department of Health and Human Services,

“Heart Disease Facts.” Heart Disease, Centers for Disease Control and Prevention, 28 Nov. 2017,

Helfand, Carly. “Bristol-Myers, AstraZeneca in Legal Hot Seat over Onglyza Heart Failure Warning.” FiercePharma, 8 May 2017,

“Onglyza Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing.” WebMD, WebMD,

“Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus | NEJM.”New England Journal of Medicine, Oxford University Press, 3 Oct. 2013,

“What Is Cardiovascular Disease?” American Heart Association,

Last Modified: May 25th, 2021 @ 03:48 pm

What is Onglyza and Kombiglyze XR?

Onglyza and Kombiglyze XR are two medications used to treat Type 2 diabetes, but in recent years, have generated concern in regards to the dangerous side effects associated. Lawsuits alleging the drugs caused heart failure and pancreatic cancer have been filed. If you believe you suffered as a result of Onglyza's serious side effects, contact a lawyer today.