Depo Provera Meningioma Lawsuit [2026 Update]

​The Depo-Provera Meningioma Lawsuit centers on allegations that prolonged use of the contraceptive injection Depo-Provera, which contains medroxyprogesterone acetate, increases the risk of developing meningiomas—slow-growing brain tumors arising from the meninges.

In October 2024, the first federal lawsuit was filed by a woman who used Depo-Provera between 2005 and 2021 and was subsequently diagnosed with a meningioma.

As more cases emerged, plaintiffs sought consolidation of these lawsuits into a multidistrict litigation (MDL) to streamline pretrial proceedings.

In February 2025, the U.S. Judicial Panel on Multidistrict Litigation (JPML) centralized 27 federal lawsuits into The Depo-Provera Multidistrict Litigation (MDL No. 3140), assigning them to Judge M. Casey Rodgers in the Northern District of Florida.

This MDL aims to efficiently handle the growing number of cases alleging that long-term Depo-Provera usage led to meningioma development.

Plaintiffs claim that Pfizer failed to provide adequate warnings about these risks, despite studies indicating a significant association between the Depo-Provera shot and brain tumors.

Women who have filed federal lawsuits in the Depo-Provera MDL seek compensation for medical expenses, pain and suffering, and other damages, asserting that Pfizer’s negligence in informing users about potential risks has led to severe health consequences.

A significant aspect of these claims involves Depo-SubQ Provera 104, a lower-dose version of the original Depo-Provera formulation.

This alternative contains a reduced concentration of medroxyprogesterone acetate and is administered subcutaneously, potentially offering a safer contraceptive option.

Plaintiffs argue that despite having this safer alternative available, Pfizer did not adequately promote or inform healthcare providers and patients about Depo-SubQ Provera 104.

They contend that the company’s continued emphasis on the higher-dose Depo-Provera formulation, without sufficient disclosure of its associated risks, constitutes negligence.

This underpromotion of the lower-dose option is presented as evidence that Pfizer prioritized its own interests over patient safety.

If you’ve developed a brain tumor after receiving Depo-Provera injections for a prolonged period of time, you may be eligible to file a Depo Provera Lawsuit and seek financial compensation.

Contact our Depo-Provera Lawyers for a free consultation, or use the chat feature on this page to find out if you’re eligible to file a Depo Provera Lawsuit instantly.

The Depo Provera Lawsuit is NOT a Class Action Lawsuit

Lawsuits involving Depo-Provera use and brain tumors are not a class action lawsuit but are instead being handled as a multidistrict litigation (MDL).

In a class action lawsuit, all plaintiffs are grouped into a single case, and any compensation is divided equally among participants.

However, in an MDL, each person who files a Depo-Provera lawsuit has an individual claim, meaning their compensation depends on the severity of their injuries and other case-specific factors.

This structure allows women who developed meningiomas after using Depo-Provera to present their unique medical history and damages rather than being treated as part of a single group.

If you or a loved one have suffered serious health complications from long-term Depo-Provera use, you may have the right to sue Pfizer individually while benefiting from the efficiency of MDL proceedings.

Projected Depo-Provera Settlements

Depo-Provera Lawsuits are in the early stages, and specific settlement amounts have yet to be determined.

However, lawyers anticipate that individual Depo-Provera settlements could range from $100,000 to $500,000 or more, depending on various factors.

Factors influencing potential Depo-Provera settlements include:

• Severity of Injuries: The seriousness of the brain tumor and its impact on the individual’s health and daily life.​
• Medical Expenses: Costs incurred for treatments, surgeries, hospital stays, medications, and ongoing care.​
• Impact on Quality of Life: The extent to which the tumor and its treatment have affected the individual’s physical abilities, mental health, and overall well-being.​
• Lost Wages and Earning Capacity: Income lost due to the inability to work during treatment and recovery, as well as any long-term or permanent disability affecting future earning potential.​
• Pain and Suffering: Non-economic damages related to physical pain, emotional distress, and mental anguish resulting from the diagnosis and treatment.

It’s important to note that these figures are projections, and actual settlement amounts will depend on the specifics of each case.

If you or a loved one has developed a brain tumor after using Depo-Provera, consulting with an experienced attorney can provide more personalized information regarding potential compensation.

​Recent studies, including a landmark study in the British Medical Journal, have identified a significant association between the use of Depo-Provera, a birth control shot containing medroxyprogesterone acetate, and an increased risk of developing intracranial meningiomas, a type of brain tumor. ​

Key findings from these studies include:

• Increased Risk with Prolonged Use: Women who used Depo-Provera for 12 months or more were found to have a 5.76-fold higher risk of developing meningiomas compared to non-users.
• Dose-Response Relationship: The risk of meningioma was observed to increase with higher doses or chronic use of Depo-Provera and other progestogens.
• Comparison with Other Contraceptives: While Depo-Provera is an injectable form of birth control, other contraceptives, such as birth control pills containing different hormonal compositions, were not specifically implicated in the increased risk of meningiomas in these studies.​

Depo Provera’s Label Has Not Been Changed in the United States

​Pfizer and other manufacturers continue to sell Depo-Provera without updating the U.S. label to warn about the increased risk of brain tumors.

This omission persists despite regulatory actions in other countries acknowledging these risks.

In September 2024, the European Medicines Agency (EMA) recommended adding a warning about the risk of meningioma to the Depo-Provera label in Europe.

Similarly, the Canadian label for Depo-Provera has mentioned meningiomas as a potential post-market adverse drug reaction for nearly a decade.

However, as of March 2025, the U.S. Food and Drug Administration (FDA) has not mandated a similar warning, and Pfizer has not independently updated the U.S. label to reflect these serious risks.

This discrepancy has raised concerns among healthcare professionals and patients about the transparency and safety information provided to U.S. consumers.

The absence of updated warnings in the U.S. has also become a central issue in ongoing lawsuits against Pfizer, with plaintiffs alleging that the company failed to adequately inform users of the potential dangers associated with prolonged Depo-Provera use.

Severe Health Issues Associated with Brain and Spinal Cord Tumors

Meningiomas, tumors that form in the membranes surrounding the brain and spinal cord, present significant health risks that can drastically affect a person’s quality of life.

These tumors can cause severe headaches, cognitive impairment, and neurological deficits depending on their size and location.

Many individuals with meningiomas experience worsening symptoms over time, including weight gain, vision problems, and difficulty with coordination.

In some cases, meningiomas can lead to serious complications such as blood clots, seizures, or hormonal disruptions, impacting menstrual periods and overall hormonal balance.

Treatment for these tumors often requires invasive procedures such as brain surgery or radiation, both of which carry their own risks and long-term consequences.

Severe Health Issues Linked to Meningiomas:

• Severe headaches that worsen over time and impact daily activities
• Cognitive decline and memory issues affecting work and personal life
• Weight gain due to hormonal imbalances or steroid treatments
• Blood clots increasing the risk of stroke or cardiovascular complications
• Seizures and neurological impairments caused by tumor pressure on brain structures
• Vision disturbances including blurred or double vision
• Hormonal imbalances affecting menstrual periods and overall endocrine function
• Surgical risks and post-operative complications following brain tumor removal
• Long-term disability requiring ongoing medical treatment and rehabilitation

Women who have developed intracranial meningioma brain tumors after prolonged use of Depo-Provera may be eligible to file a lawsuit against Pfizer, Pharmacia LLC, and other manufacturers.

The Depo-Provera Lawsuit alleges that Pfizer failed to warn users and healthcare providers about the increased risk of brain tumors linked to long-term use of the contraceptive injection.

If you received multiple Depo-Provera shots and were later diagnosed with a meningioma or other serious brain tumor, you may have a case.

If you believe that prolonged use of Depo-Provera caused your brain tumor, contact our law firm for a free consultation.

Our attorneys will evaluate your medical history, review your records, and determine if you meet the criteria for the Depo-Provera multidistrict litigation (MDL).

Use the chat feature on this page to find out if you qualify for a Depo-Provera case instantly.

Taking legal action can help you seek compensation for medical expenses, lost wages, pain and suffering, and other damages caused by this dangerous drug.

Gathering Evidence for a Depo Provera Lawsuit

To build a strong Depo-Provera Lawsuit, plaintiffs must provide clear evidence linking their use of the contraceptive injection to the development of a benign brain tumor such as meningioma.

Medical records are crucial in proving a history of long-term Depo-Provera usage and a subsequent brain tumor diagnosis, which are key factors in these legal claims.

Our attorneys will help you gather, review, and organize all necessary evidence to support your case.

Evidence for a Depo Provera Lawsuit may include:

• Medical records documenting Depo-Provera injections and treatment history.
• Doctor’s notes confirming a diagnosis of intracranial meningioma or other brain tumors.
• Prescription history showing prolonged use of Depo-Provera.
• Imaging scans such as MRIs or CT scans confirming tumor size and location.
• Billing records detailing medical expenses related to treatment, surgery, or ongoing care.
• Expert medical opinions linking the brain tumor to Depo-Provera usage.
• Personal testimony describing symptoms, treatment, and the impact of the condition.

Damages in Depo Shot Lawsuits

In a Depo-Provera Lawsuit, damages refer to the financial, physical, and emotional losses suffered by individuals who developed brain tumors after prolonged use of the contraceptive injection.

These damages help compensate for medical expenses, lost income, pain and suffering, and other hardships caused by the diagnosis.

Our attorneys will assess your case, calculate potential compensation, and fight for the maximum Depo-Provera settlement available.

Damages in a Depo-Provera Brain Tumor Lawsuit may include:

• Medical expenses related to brain tumor treatment, including MRIs, CT scans, and surgery.
• Ongoing healthcare costs for managing long-term complications.
• Lost wages due to missed work or an inability to return to employment.
• Pain and suffering caused by the effects of the tumor and necessary treatments.
• Emotional distress resulting from the diagnosis and the impact on daily life.
• Loss of quality of life due to cognitive or physical impairments.

TorHoerman Law is committed to helping individuals who have developed brain tumors after prolonged use of the Depo-Provera birth control shot.

Our experienced legal team understands the serious health and financial burdens that come with a brain tumor diagnosis, and we are actively investigating claims against Pfizer for failing to warn about these risks.

With a proven track record in pharmaceutical litigation, we are prepared to fight for justice and fair compensation for those affected.

If you or a loved one used Depo-Provera and were later diagnosed with a meningioma or other brain tumor, you may have legal options.

Our firm provides a straightforward, no-obligation consultation to review your case and determine your eligibility for a lawsuit.

We work on a contingency fee basis, meaning you pay nothing unless we win compensation on your behalf.

Contact TorHoerman Law today for a free case evaluation.

Use the chat feature on this page or call us now to get started on your Depo-Provera Lawsuit.